Slow-to-moderate weight loss via anti-obesity drugs may reduce mortality risk among osteoarthritis patients: Study

The current guidelines recommend weight loss for patients with overweight or obesity and knee or hip osteoarthritis (OA); however, there is a paucity of data on the relation of weight loss to death among patients with osteoarthritis. We aimed to examine the relation of the rate of weight loss induced by antiobesity medications over one year to all-cause mortality among patients with overweight or obesity and knee or hip osteoarthritis. Using the IQVIA Medical Research Database, we identified people with overweight or obese and had knee or hip osteoarthritis. We emulated analyses of a hypothetical target trial to assess the effect of slow-to-moderate (2%–10%) or fast (≥10%) weight loss induced by the initiation of antiobesity medications within one year on all-cause mortality and secondary outcomes over five years’ follow-up. Results: Among 6,524 participants, the five-year all-cause mortality rates were 5.3%, 4.0%, and 5.4% for weight gain or stable, slow-to-moderate weight loss, and fast weight loss arms, respectively.