Study Finds U-Shaped Link Between TyG-BMI and Mortality Risks in Osteoarthritis Patients, Highlighting IR Role
China: A recent analysis of National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2020 has unveiled a U-shaped nonlinear relationship between the triglyceride glucose-body mass index (TyG-BMI) and both all-cause and cardiovascular mortality among adults with osteoarthritis (OA) in the United States.
The findings, published in Scientific Reports, highlight the complex role that insulin resistance (IR) plays in the health outcomes of these patients.
"Mortality risks escalated when TyG-BMI levels exceeded thresholds of 282 for all-cause mortality and 270 for cardiovascular mortality. For each 10-unit increase above these thresholds, there was a corresponding 3% rise in the risk of all-cause mortality and a 5% increase in cardiovascular mortality risk," the researchers reported.
The TyG-BMI index, a composite measure combining triglyceride levels, glucose levels, and body mass index, has been increasingly recognized for its potential in assessing metabolic health and the risk of adverse outcomes. The relationship between insulin resistance and all-cause and cardiovascular mortality risk in osteoarthritis patients is still unclear. Considering this, Wenbo Ding, China Medical University, Liaoning, People’s Republic of China, and colleagues aimed to clarify the correlation between a novel marker of IR, the TyG-BMI index, and the risk of all-cause mortality and cardiovascular mortality in OA patients.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.