Tapentadol PR improves pain, QoL in osteoarthritis patients

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2020-02-07 10:15 GMT | Update On 2020-02-07 10:15 GMT

Germany: Tapentadol prolonged-release (PR) is a useful strong analgesic to improve pain intensity, physical functioning and quality of life in elderly osteoarthritis (OA) patients, according to a recent study published in the journal Pain Management.

Osteoarthritis is a painful and debilitating disease of joints. It affects the entire joint, involving the cartilage, joint lining, ligaments, and bone. Pain and disability is the hallmark of osteoarthritis and it has become one of the leading cause of disability in older adults, affecting 9.6% of elderly men and 18% of elderly women. OA pain leads to severe impairments in physical functioning and quality of life.

Christian Elling, Grünenthal GmbH, Aachen, Germany, and colleagues extracted data of patients with severe chronic knee and/or hip OA pain from the database of a prospective, noninterventional trial to assess the benefits of tapentadol prolonged-release in elderly patients (>65 years of age; n = 1162) compared with younger patients (≤65 years of age; n = 498).

Pain was assessed by the Numerical Rating Scale (scores 0-10, with 10 being worst pain). QoL was assessed by the Short Form-12 (scores 0-100, with 100 being least disabled).

Key findings of the study include:

53.5% of the elderly at baseline had been in pain for >2 years vs 49% of nonelderly.
After 3 months of treatment with tapentadol PR:

Pain was reduced by 3.8 points in elderly (52.1%) and 4 points in nonelderly patients (54.8%).
QoL (physical component) rose by 11.8 points in elderly and 12.3 points in nonelderly patients.
QoL (mental component) rose by 12.4 points in elderly and 13.5 points in nonelderly patients.
AEs occurred in 2.4% of elderly and 3.4% of nonelderly patients.

"Tapentadol PR is tied to reduced pain and improved QoL with a low rate of adverse events (AEs) in elderly patients with osteoarthritis (OA)," concluded the authors.

The study, "Tapentadol prolonged release for severe chronic osteoarthritis pain in the elderly: improvements in daily functioning and quality of life," is published in the journal Pain Management.

DOI: https://doi.org/10.2217/pmt-2019-0041

Article Source : journal Pain Management

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Medha Baranwal

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Tapentadol PR improves pain, QoL in osteoarthritis patients

Similar News

Osteosarcopenia in Prediabetic Adults Linked to Nearly 3-Fold Higher Osteoarthritis Risk: NHANES Study

Robotic Innovations in Orthopedics

TNF Inhibitor linked to Remission in Early axSpA regardless of Gut Inflammation: Study

Biocon Biologics gets EU nod for bone disease treatments, including Osteoporosis, giant cell tumour of bone

CKC exercises more effective than conventional therapy in improving function in DRF rehabilitation: study

Lichen Planopilaris Linked to Elevated Risk of Autoimmune, Skin, and Heart Conditions: Meta-Analysis

JAK Inhibitors Linked to Higher Cancer Risk in RA Patients: Study

Physical Therapy Outperforms Steroid Injections for Meniscus Tears with Knee Osteoarthritis: Study