Use of antiepileptic Drugs increases risk of hip fracture in Alzheimer's Disease: Study
According to a recent study published in the Journal of Clinical Epidemiology, it has been observed that antiepileptic drugs (AED) use is associated with an increased risk of hip fracture in people with Alzheimer´s disease (AD).
Hip fractures are indeed a major health problem in older adults, and strongly affect their health and well-being, substantially increasing morbidity, short-term mortality, and reducing autonomy and quality of life. As a result, health-care costs are also substantially increased.
Hence, Pisa F, Reinold J and associates from the School of Pharmacy, University of Eastern Finland, Kuopio, Finland carried out this study to determine the risk of hip fracture in persons with Alzheimer´s disease (AD) who initiated antiepileptic drugs (AEDs).
This cohort of 70,719 Finnish community dwellers with clinically verified incident AD diagnosis were identified and registered for the study. AEDs were classified as older (valproate, carbamazepine, clonazepam, phenytoin, levetiracetam, primidone) or newer (pregabalin, gabapentin, oxcarbazepine, lamotrigine, topiramate). The authors further matched each user to 2 non-users. Incident hip fractures were identified from the Care register for health care. The inverse probability of treatment weighted hazard ratios (HR), with 95% confidence intervals, using Cox regression was calculated.
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