Vitamin D deficiency in hip fracture patients associated with increased mortality: study
John M. Bayram et al conducted a study to assess whether vitamin D deficiency influenced mortality risk and length of acute hospital stay in patients presenting with a hip fracture. The study was conducted at Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, UK.
Vitamin D deficiency is defined by the Endocrine Society Task Force as a serum 25-hydroxyvitamin D [25(OH)D] level < 50 nmol/l.
A retrospective study was undertaken including all patients aged over 50 years that were admitted with a hip fracture to a single centre during a 24-month period. Serum vitamin D levels on admission, patient demographics, perioperative variables and mortality were collected. Cox regression analysis was utilised to determine the independent association between serum vitamin D levels and patient mortality.
Key findings of the study were:
• The cohort consisted of 1510 patients with a mean age of 81.3 years and 1107 (71.4%) were female. 876 (58.0%) were vitamin D deficient (< 50 nmol/l).
• The median follow up was 405 (IQR 249 to 610) days. During follow-up there were 464 deaths (30.7%). Vitamin D deficiency was independently associated with higher mortality risk (hazard ratio [HR] 1.26, 95% confidence interval (CI) 1.03 to 1.53, P = 0.022).
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