Weight fluctuation tied to advese CV events in Rheumatoid Arthritis

Out of the total sample size, the investigators observed that those patients who lost or gained 10% of their weight had greater disease activity, worse physical function, and were more likely to smoke, have diabetes, use corticosteroids and be disabled.

Based on the study, the authors noted the following key findings-

1. A greater risk of CV events was observed in those that experienced 10% weight loss [HR: 1.18 (1.03,1.36) p=0.02] or weight gain [HR 1.20 (1.04,1.38) p=0.01].
2. The association between weight change and CV events was stronger among participants with BMI <25 kg/m² for 10% weight loss [HR: 1.34 (1.08,1.66) p=0.001] and 10% weight gain [1.74 (1.41,2.24) p<0.001].
3. Patients with greater variability in weight had a higher risk of CV events.

Therefore, the authors concluded by saying that "Recent changes and high variability in weight predict CV events in RA, particularly among thin patients. Further study is necessary to determine if weight fluctuation has adverse cardiometabolic consequences that are independent of other risk factors."

For further reference log on to:

Baker JF, et al. Arthritis Care Res. 2020;doi:10.1002/acr.24469