Maternal COVID-19 infection may lead to brain injury in fetal brain: Case report
USA: The study published in the Journal of the American Academy of Pediatrics reported two cases of infants born to mothers with COVID-19 who showed early-onset seizures, acquired microcephaly, and significant developmental delay over time.
The COVID-19 pandemic has had a profound effect on global health and has resulted in unfavorable maternal and fetal outcomes. The study highlights the occurrence of severe neurological damage in two infants: one a preterm baby born at 32-week gestational age and the other a full-term baby born at 39-week gestational age. Notably, neither infant tested positive for the SARS-CoV-2 virus through RT-PCR.
The two infants were born without the virus but with detectable COVID-19 antibodies and increased blood inflammatory markers, had severe parenchymal atrophy and cystic encephalomalacia according to sequential MRI scans. Both infants suffered an ongoing neurologic injury and developmental deficits, with one experiencing sudden death at 13 months of age and extensive loss of brain white matter, gliosis, and vacuolization at autopsy.
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