Acetaminophen with ibuprofen therapy effective in febrile children: Study
A new study published in the journal of Pediatrics showed that when treating children with fever, combination therapy may be more effective than monotherapy. Since fever is a common early clinical sign of acute infections, it has long been a symptom of great worry to parents and clinicians. Parents frequently experience worry and anxiety when their child has refractory fever, which is characterized by a poor response to an antipyretic medication or a fever return prior to the next pharmacological dose.
Despite worries about possible medication toxicity and negative interactions, children with refractory fever have been treated in practice using a regimen of alternating acetaminophen and ibuprofen at various doses and intervals. Also, the safety of alternating antipyretic treatment has not yet been shown, and the risk of improper and excessive administration is increased by the probability that parents may not comprehend dosage recommendations. It is unclear if the effects and safety of acetaminophen and ibuprofen as single or dual (alternating or combination) therapy are comparable. Thus, using a systematic review and network meta-analysis, Juan and his colleagues carried out this study to evaluate the relative effectiveness of acetaminophen, ibuprofen alone, alternating, or in combination.
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