Adverse kidney outcomes common in wilms Tumor survivors, Finds study

Recent kidney ultrasound examinations and echocardiograms were reviewed for contralateral kidney size and left ventricular hypertrophy, respectively. Clinical follow-up data were collected for approximately 2 years after study enrollment.

The results showed that -

a. Thirty-two participants (median age, 13.6 years [IQR, 10.5-16.3 years]; 75% stage 3 or higher WT) were evaluated at a median of 8.7 years (IQR, 6.5-10.8 years) after therapy; 29 participants underwent unilateral radical nephrectomy, 2 bilateral partial nephrectomy, and 1 radical and contralateral partial nephrectomy.

b. In this cohort, 72% received kidney radiotherapy and 75% received doxorubicin. c. Recent median eGFR was 95.6 mL/min/1.73 m2 (IQR, 84.6-114.0; 11 [34%] had an eGFR of <90 mL/min/1.73 m2).

d. Abnormal ABPM results were found in 22 of 29 participants (76%), masked hypertension in 10 of 29 (34%), and microalbuminuria in 2 of 32 (6%).

e. Of the 32 participants, 22 (69%) had abnormal epidermal growth factor; few had abnormal kidney injury molecule-1 or interleukin-18.

f. Seven participants with previous unilateral nephrectomy lacked compensatory contralateral kidney hypertrophy.

g. None had left ventricular hypertrophy.

Therefore, the authors concluded that "in survivors of WT, adverse kidney outcomes were common and should be closely monitored."