Citicoline effective in kids with hypoxic-ischemic encephalopathy
A new study published in the Italian Journal of Pediatrics suggests that citicoline has the potential to be a promising neuroprotective medication in newborns with hypoxic-ischemic encephalopathy (HIE).
One of the biggest problems that might result in neonatal mortality or impairment is hypoxic-ischemic encephalopathy. As a result, Abeer Salamah and colleagues undertook this study to evaluate the impact of citicoline as a neuroprotector in infants with mild to severe HIE.
This study included 80 newborns with mild to severe HIE who were not eligible for therapeutic cooling. They were randomly separated into two groups: the citicoline treatment group, which comprised 40 newborns who received citicoline 10 mg / kg /12 h IV for 4 weeks along with additional supportive measures, and the control group, which included 40 neonates who got placebo along with the same supportive measures. All patients were assessed for the length of mechanical ventilation (MV), the necessity for inotropes, seizures, and NICU stay. After 4 weeks of therapy, all enrolled neonates had cranial ultrasounds and brain magnetic resonance imaging (MRI). All newborns were followed up on for neurodevelopmental outcomes at 3, 6, 9, and 12 months.
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