Cord blood may benefit autistic children without an intellectual disability only

Published On 2020-05-24 08:10 GMT   |   Update On 2020-05-25 08:10 GMT
Advertisement

DURHAM, N.C. -- In a recent study, Duke researchers tested whether a single infusion of a unit of a child's own or donor cord blood could improve social communication skills in children between the ages of 2-7 diagnosed with an autism spectrum disorder.

Of the 180 children in the study, the subgroup of children without an intellectual disability showed improvements in language communication, ability to sustain attention measured via eye-tracking, and increased alpha and beta EEG power, a measure of brain function.

Advertisement

However, those who also had an intellectual disability did not show social communication function improvement after the infusion.

The findings are publishing online in The Journal of Pediatrics.

"Cord blood contains immune-modulating cells called monocytes," said Joanne Kurtzberg, M.D., Jerome S. Harris Distinguished Professor of Pediatrics, director of the Marcus Center for Cellular Cures and a pioneer in the use of cord blood treatments. "In the laboratory, these cells calm down a type of brain inflammation that can be seen in children with autism. In this study, we tested whether cord blood infusions would lessen symptoms in children with autism."

Approximately 40 percent of children with autism also have an intellectual disability, as defined as an IQ below 70, according to first author Geraldine Dawson, Ph.D., director of the Duke Institute for Brain Sciences and the William Cleland Distinguished Professor of Psychiatry and Behavioral Sciences.

More research is needed to determine why the findings in this study are different between those with and without an intellectual disability, and whether the treatment could be altered to be beneficial to more children.

"It is unclear whether the failure for children with an intellectual disability is due to the short duration of the study, the outcome measures not being sensitive enough to detect a change in this population or that the cord blood is actually not an effective treatment for children with autism who also have an intellectual disability," Dawson said.

"We learned a lot from this initial study," said Kurtzberg, senior author on the manuscript. "In the future, we hope to conduct a trial designed for children with autism who have intellectual disability focusing on outcome measures that can be targeted to test this group of children. We also used lessons learned from this study to design an ongoing study testing other cell therapies in older children with autism without intellectual disability."

"Overall, we are encouraged by these initial results and plan to build upon them in future studies of cellular therapies in children with autism," Kurtzberg said.

Tags:    
Article Source : The Journal of Pediatrics

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News