CRP levels of no consequence in infection management in infants: JAMA
UK: Serum C-reactive protein (CRP) level is not sufficiently accurate to aid diagnosis or to inform treatment decisions in infants with suspected late-onset infection, a recent review in the journal JAMA Pediatrics has suggested.
According to the study, determination of serum CRP level of an initial evaluation of an infant with suspected late-onset infection is unlikely to aid early diagnosis or to select infants to undergo further investigation or treatment with antimicrobial therapy or other interventions.
Jennifer Valeska Elli Brown, Centre for Reviews and Dissemination, University of York, York, United Kingdom, and colleagues conducted this systematic review and meta-analysis of 22 cohort studies to compare the accuracy of serum C-reactive protein (CRP) with that of microbiological blood culture for diagnosing late-onset infection in newborns.
The review included 22 cohort and cross-sectional studies comprising of 2255 infants. The studies that compared the accuracy of serum CRP levels with microbiological culture results to diagnose late-onset (>72 hours after birth) infection in newborns (any gestational age) hospitalized after birth were included.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.