Disrupted Insulin sensitivity and adiposity in kids tied to psychosis in later life: JAMA
Cardiometabolic disorders often occur concomitantly with depression and schizophrenia, leading to a reduced quality of life, increased health care costs, and a shortened life expectancy. Traditionally, this comorbidity has been attributed to chronic lifestyle factors or the adverse effects of psychotropic medications. In a recent study, researchers have found that disrupted insulin sensitivity could be a shared risk factor for comorbid cardiometabolic disorders and psychosis. They also reported that puberty-onset major increase in BMI could be a risk factor or risk indicator for adult depression. The study findings were published in the JAMA Psychiatry on January 13, 2021.
Existing studies have predominantly included prevalent depression or psychosis cases which cannot appropriately test the direction of the association between cardiometabolic and psychiatric phenotypes. The most longitudinal studies have included one-off measures of cardiometabolic indices, overlooking dynamic temporal changes in these markers. It is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated with risks for adult psychosis and depression. Therefore, researchers of the University of Cambridge School of Clinical Medicine, UK conducted a study to examine whether specific developmental trajectories of fasting insulin (FI) levels and body mass index (BMI) from early childhood were longitudinally associated with psychosis and depression in young adults.
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