High dose of vitamin D supplements improves insulin resistance in obese kids

The key findings of this study were:

1. After retrieving 1502 publications, 10 studies that qualified for inclusion were made up of 595 participants in total.

2. Meta-analysis revealed no differences between the vitamin-D (Vit-D) group and the placebo group in terms of LDL, TC, BMI, TG, Ca, ALP, and PTH; however, the Vit-D group had better HOMA-IR.

3. The rise in 25-(OH)-D was not significantly different between subgroups, according to subgroup analysis (p = 0.39), although the serum 25-(OH)-D level rose in response to various Vit-D dosages.

4. A high daily dosage of vitamin D ( 4000 IU/d) may lower CRP and raise HDL levels.

In conclusion, supplementing with vitamin D wouldn't help OW/OB children and adolescents' BMI, LDL, TG, PTH, TC, Ca, and ALP levels. A high dose of vitamin D supplementation (above 4000 IU/d) might improve insulin resistance and lower a number of cardiometabolic risk markers. More large-scale, high-quality RCTs are required to produce more reliable data.

Reference:

Gou, H., Wang, Y., Liu, Y., Peng, C., He, W., & Sun, X. (2022). Efficacy of vitamin D supplementation on child and adolescent overweight/obesity: a systematic review and meta-analysis of randomized controlled trials. In European Journal of Pediatrics. Springer Science and Business Media LLC. https://doi.org/10.1007/s00431-022-04673-8