High pretreatment LDH raises mortality risk in children with adenoviral pneumonia
China: A new research from China found that high pretreatment lactate dehydrogenase (LDH) may increase the risk of mortality in children with adenoviral pneumonia (ADVP) as it is associated with disease severity, development of postinfectious bronchiolitis obliterans (PIBO). The study results were published in the journal Frontiers in Pediatrics.
Adenoviruses are ubiquitous DNA viruses that cause a wide variety of illnesses in children and adults, including pneumonia. Severe adenoviral pneumonia (ADVP) in children has a poor prognosis and a high risk of mortality. Min Zou et al from Guangxi International Zhuang Medical Hospital, China conducted a meta-analysis to evaluate the association between pretreatment lactate dehydrogenase (LDH) and severity, postinfectious bronchiolitis obliterans (PIBO), and mortality in children with ADVP.
Researchers included relevant observational studies by searching databases like PubMed, Embase, Web of Science, Wanfang, and CNKI databases from inception to August 3, 2022. The results were pooled using a random effect model by incorporating the potential between-study heterogeneity.
Key findings:
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