High prevalence of Sarcopenic Obesity among survivors of childhood ALL-study
Obesity is recognized as a common chronic health problem among survivors of childhood cancer; is also known to increase risk of metabolic syndrome and cardiovascular disease. As Acute Lymphoblastic leukemia(ALL) is commonest childhood cancer, researchers from Rajiv Gandhi Cancer Institute, Delhi aimed to study prevalence of childhood obesity and sarcopenia among survivors of childhood ALL.
In this case control study, 65 cases who were survivors of ALL (<18yrs at diagnosis) were analysed at 5 years of completion of therapy and matched with healthy sibling controls. All the cases received BFM protocol for treatment of ALL. Dual energy Xray absorbometry(DEXA) and BMI were used to study body fat composition.
Key findings of the study are:
1. The mean body fat percentage (BF%) was significantly higher among ALL survivors as compared to sibling controls(p=0.001).
2. Obesity was observed among 21.5 %( 14 out of 65) cases and overweight among 55% of cases at follow up.
3. Also body fat mass index(BFMI) was significantly higher among survivors of ALL(p<0.001)
4. High prevalence of sarcopenic obesity was observed among survivors which was not seen in controls.
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