High sensitivity CRP maybe higher in children suffering from dengue, Study says

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-05-19 03:30 GMT | Update On 2021-05-19 03:30 GMT

Researchers from a recent study have found significantly higher level of hs-CRP in dengue children as compared to healthy controls. However, no significant difference in hs-CRP level could be found between severe and non-severe dengue patients.

The study is published in the International Journal of Pediatric Research.

Hs-CRP, being used in this study to assess the level of CRP, has low detection threshold of measurement as compared to conventional CRP. Hs-CRP has been evaluated in children with asthma, nephrotic syndrome and type 1 diabetes mellitus.

However, no study has been done in children to see hs-CRP levels in dengue patients. Hence, Aaradhana and associates from the Department of Pediatrics, Guru Teg Bahadur Hospital, University College of Medical Sciences, India planned this study to see the utility of hs-CRP in identification of severe dengue in children.

Objectives of this study were to compare hs-CRP levels between children with dengue and healthy comparison groups and between severe and non-severe dengue cases.

The authors conducted this descriptive cross-sectional study to compare hs-CRP levels between a group of 31 children under 12 year of age with dengue (positive NS1 antigen and/IgM ELISA for dengue) and healthy comparison group and between severe and non-severe dengue cases. Hs-CRP levels were assessed in sera of hospitalized dengue cases and healthy controls.

The results revealed that-

a. Median (IQR) hs-CRP levels were 46.59 (34.8, 67.0) mg/L and 0.530 (0.00, 2.79) mg/L respectively in dengue cases and healthy controls which was statistically significant (p < 0.001).

b. Median (IQR) hs-CRP levels in severe and non-severe dengue patients were 46.59 (34.77, 68.43) and 46.67 (24.33, 63.79) mg/L respectively which was statistically not significant (p = 0.85).

Hence, the authors concluded that " Hs-CRP level was significantly higher in dengue children as compared to healthy controls. But no significant difference in hs-CRP level was found between severe and non-severe dengue patients."

Article Source : International Journal of Pediatric Research

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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High sensitivity CRP maybe higher in children suffering from dengue, Study says

Objectives of this study were to compare hs-CRP levels between children with dengue and healthy comparison groups and between severe and non-severe dengue cases.

The results revealed that-

a. Median (IQR) hs-CRP levels were 46.59 (34.8, 67.0) mg/L and 0.530 (0.00, 2.79) mg/L respectively in dengue cases and healthy controls which was statistically significant (p < 0.001).

b. Median (IQR) hs-CRP levels in severe and non-severe dengue patients were 46.59 (34.77, 68.43) and 46.67 (24.33, 63.79) mg/L respectively which was statistically not significant (p = 0.85).

Hence, the authors concluded that " Hs-CRP level was significantly higher in dengue children as compared to healthy controls. But no significant difference in hs-CRP level was found between severe and non-severe dengue patients."

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