Ibuprofen may increase risk of hospital-acquired AKI in hospitalized children: JAMA
Researchers have recently observed that Ibuprofen is widely used and is associated with a significantly increased risk of hospital-acquired AKI in hospitalized children particularly children with CKD, of older age, or in need of intensive care.
The study is published in the JAMA Open Network.
Ibuprofen is widely used in children worldwide, especially in those with cancer, fever, or trauma. However, large and high-quality studies of the association between ibuprofen and acute kidney injury (AKI) in children have been lacking.
Therefore, Licong Su and colleagues from the Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China conducted this cohort study to examine the association between the use of ibuprofen and the risk of hospital-acquired AKI in hospitalized children in China.
The authors analyzed the cohort of the Epidemiology of AKI in Chinese Hospitalized Patients (EACH) study, a large, multicenter retrospective study of 3 044 023 patients who were admitted to 1 of 25 academic medical centers in China. Patient-level data were obtained from the electronic health record system of the participating centers. Hospitalized children aged 1 month to 18 years who had prescriptions and a certain number of serum creatinine (SCr) tests were included.
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