ICSI use for infertility may increase risk of ASD and developmental delay in offsprings: JAMA
ICSI has an unfavorable implication for the neurodevelopmental health of offspring in couples with either male or female infertility suggests a recent study published in the JAMA Network Open.
Intracytoplasmic sperm injection (ICSI), the most common type of assisted reproductive technology (ART), might damage the sperm or embryo. The implications of male infertility and ICSI for the neurodevelopmental health of offspring remain unknown. A study was conducted to analyze the risks of neurodevelopmental disorders in offspring of couples with male or female infertility with or without ICSI use.
Results of this study suggest that male infertility was not associated with an increased risk of neurodevelopmental disorders in offspring. In both male and female infertility groups, ICSI had unfavorable implications for the neurodevelopmental health of offspring in terms of increased risks of ASD and developmental delay.
Reference:
Lo H, Weng S, Tsai E. Neurodevelopmental Disorders in Offspring Conceived via In Vitro Fertilization vs Intracytoplasmic Sperm Injection. JAMA Netw Open. 2022;5(12):e2248141. doi:10.1001/jamanetworkopen.2022.48141
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