JAMA: Early Treatment with Antivirals Effective in Children with Hepatitis C
A recent study published in the Journal of American Medical Association unveiled a promising findings regarding the efficacy and cost-effectiveness of early treatment for children with perinatally acquired hepatitis C virus (HCV) infection in the United States.
This study looks into the pressing need for interventions as HCV transmission from mother to child which continues to pose a significant health concern by affecting approximately 7% to 8% of births. With the recent approval of direct-acting antiviral (DAA) therapy for children aged three years and older, Megan Rose Curtis and team evaluated the clinical and economic impacts of initiating treatment at various ages.
After utilizing a sophisticated state-transition model, this research projected outcomes for a cohort of 1000 children with perinatally acquired HCV from the age of three years until death. By offering DAA therapy at ages three, six, twelve, and eighteen years along with a scenario of never treating HCV, this research examined life expectancy, healthcare costs and clinical outcomes including cirrhosis and hepatocellular carcinoma (HCC).
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