Lactic acidosis a frequent complication of asthma in children, claims study
A recently published study in the European Journal of Pediatrics have suggested that Lactic acidosis is a frequent complication of acute asthma in the paediatric population. The research team further estimated that age older than 6 years, hyperglycaemia, and nebulised salbutamol are risk factors for lactic acidosis during asthma.
Lactic acidosis is another blood gas alteration observed during moderate or severe asthma. Multiple mechanisms have been proposed. Some have evoked reduced tissue perfusion or overuse of respiratory muscles under hypoxic conditions. Others have suggested that b2-adrenergic agents like bronchodilators used to treat asthma lead to increased gluconeogenesis, glycogenolysis, glycolysis, and lipolysis, cumulating in lactic acid production.
Even though Lactic acidosis is now a well-known complication of status asthmaticus in adults, data is rare in children.
So, with the aim to describe the prevalence and risk factors contributing to lactic acidosis in children treated with salbutamol for moderate or severe acute asthma, a team of researchers under Marta Ruman, from the Children's Hospital, Service of Paediatrics, Switzerland undeetook the study .
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