Live-Attenuated RSV Vaccine Shows Immunogenicity in Children: Journal of Infectious Diseases
Respiratory syncytial virus (RSV) is a significant cause of lower respiratory illness (LRI) in pediatric populations. With the need for an effective vaccine, Ruth Karron and team have explored RSV/6120/ΔNS2/1030s, a cDNA-derived live-vaccine candidate. The findings were published in The Journal of Infectious Diseases.
To evaluate the safety and immunogenicity of the RSV/6120/ΔNS2/1030s vaccine, a double-blind, placebo-controlled trial was conducted. The trial administered a single intranasal dose of the vaccine at different levels of plaque-forming units (PFU) to two groups: 15 RSV-seropositive children aged 12 to 59 months and 30 RSV-seronegative children aged 6 to 24 months. The vaccine-to-placebo ratio was 2:1.
The study found that RSV/6120/ΔNS2/1030s was able to infect 100% of the RSV-seronegative children and demonstrated immunogenicity, as evidenced by the geometric mean RSV plaque-reduction neutralizing antibody titer (RSV-PRNT) of 1:91. Furthermore, the vaccine proved to be genetically stable. However, researchers observed mild rhinorrhea (runny nose) occurring more frequently in vaccinated children (18 out of 20) compared to those who received the placebo (4 out of 10) during the trial period. Notably, only one vaccinee experienced LRI during a period when only the vaccine virus was detected.
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