LPA, MPA Ratio may independently predict mortality in left congenital diaphragmatic hernia

Results

Seventy-two neonates with left CDH were included, 19 (26.4%) died or needed ECMO, and 53 (73.6%) survived without ECMO. The lower observed/expected lung-to-head ratio, lower EF, lower LPA: MPA ratio, lower RPA: MPA ratio, lower Nakata index, and lower McGoon ratio were associated with death or need for ECMO. By multivariate analysis, lower LPA: MPA ratio, RPA: MPA ratio, and Nakata index were independent postnatal risk factors for death or need for ECMO. Among the measurements, the LPA: MPA ratio had the highest area under the curve (0.957) with a sensitivity of 84.2% and specificity of 96.3% at a cut-off value of 31.2%.

In patients with left CDH, the LPA: MPA ratio measured by echocardiography could be used as an independent postnatal predictor of death or need for ECMO.

Reference:

Park, S.H., Kim, M.J., Lee, H.N. et al. Early echocardiographic pulmonary artery measurements as prognostic indicators in left congenital diaphragmatic hernia. BMC Pediatr 23, 499 (2023). https://doi.org/10.1186/s12887-023-04308-3

Keywords:

LPA, MPA, Ratio, may, independently, predict, mortality, left, congenital, diaphragmatic, hernia, BMC Pediatrics, Park, S.H., Kim, M.J., Lee, H.N