LRG1 may be early marker of DKD progression in children with T1DM

Results

There was positive correlation between LRG1 level and Schwartz and cystatin C-based eGFR decline (r = 0.360, p = 0.003; r = 0.447, p = 0.001, respectively), and negative correlation between final cystatin C-based eGFR and LRG1 (p = 0.01, r = –0.345). Patients with cystatin C-based eGFR decrease > 10% had significantly higher LRG1 levels (p = 0.03), however, LRG1 was not different between albuminuria progression subgroups. A 0.282 μg/ml increase in LRG1 correlated with a 1% decrease in eGFR in simple linear regression analysis (β = 0.282, %CI 0.11–0.45, p = 0.001) and LRG1 was an independent predictor of GFR decline even in the presence of covariates.

The study supports the relationship between plasma LRG1 and eGFR decline and suggests LRG1 may be an early marker of DKD progression in children with T1DM.

Reference:

Altıncık, S.A., Yıldırımçakar, D., Avcı, E. et al. Plasma leucine-rich α-2-glycoprotein 1 – a novel marker of diabetic kidney disease in children and adolescents with type 1 diabetes mellitus?. Pediatr Nephrol (2023). https://doi.org/10.1007/s00467-023-06019-4

Keywords:

Altıncık, S.A., Yıldırımçakar, D., Avcı, E, Plasma, leucine-rich, α-2-glycoprotein 1, novel, marker, diabetic, kidney, disease, children, adolescents, type 1 diabetes, mellitus, Pediatrics Nephrology