Maternal hypothyroidism closely related with Cardiovascular Diseases in Offspring: Study

The results stated as follow:

1. Offspring born to hypothyroid mothers had an increased risk of CVD and several subtypes of CVD, including hypertension, arrhythmia, and acute myocardial infarction.

2. The magnitude of the association was greatest when the exposure occurred during pregnancy, and this was consistent across all subgroup analyses, including sibling analysis.

3. Notably, there was a weaker association among offspring born to fathers who had hypothyroidism throughout their lives, as well as mothers who developed hypothyroidism more than five years after delivery.

4. The findings of this study add to the evidence that maternal hypothyroidism is associated with a broader spectrum of CVD in offspring than hypertension.

In conclusion, maternal hypothyroidism may have a negative impact on the cardiovascular health of her offspring from adolescence to mid-adulthood, especially if it occurs during pregnancy. Because of the associations observed for paternal hypothyroidism as well as maternal exposure more than 5 years after delivery, the effects of genetic susceptibility or common familial environmental factors cannot be completely ruled out.

Reference:

Miao, M., Liu, H., Yuan, W., Madsen, N., Yu, Y., László, K. D., Liang, H., Ji, H., & Li, J. (2021). Association of Maternal Hypothyroidism With Cardiovascular Diseases in the Offspring. In Frontiers in Endocrinology (Vol. 12). Frontiers Media SA. https://doi.org/10.3389/fendo.2021.739629