Mild COVID-19 infection during pregnancy does not slow brain development in infants: JAMA

USA: A recent study published in JAMA Network Open has found no association between prenatal exposure to maternal SARS-CoV-2 infection and infant neurodevelopment between ages 5 and 11 months. The results were based on a comprehensive assessment of brain development.

Columbia researchers found that babies born to moms with mild or asymptomatic COVID during pregnancy are normal. The findings expand on a smaller study that used maternal reports to assess the development of babies born in New York City during the first wave of the pandemic. That study found no differences in brain development between babies exposed to COVID in utero and those not exposed.

For the new study, the researchers developed a method of observing infants remotely, adapting a developmental assessment tool typically administered in person to make the study COVID-safe (babies were assessed between March 2021 and June 2022). The researchers studied 407 infants between 5 and 11 months of age from three geographic areas: New York City, Salt Lake City, Utah, and Birmingham, Alabama. Nearly a third of the infants were born to mothers who had COVID during pregnancy.

Before the evaluation, each participating family received the same set of baby toys and food items so that the researchers could observe and compare the babies’ fine and gross motor skills in a standardized fashion. The researchers also assessed cognitive and language skills. They did not know which babies had been exposed to COVID in utero.

“The idea for our novel method to assess development remotely came from Columbia clinicians who quickly began performing telehealth visits at the start of the pandemic to continue to deliver high-quality care in safe ways,” says study leader Dani Dumitriu, MD, PhD, assistant professor of paediatrics and psychiatry at Columbia University Vagelos College of Physicians and Surgeons. “But over time, we also realized that evaluating the babies remotely would allow us to observe how the babies were developing in their home environment, which may offer a better idea of how the infants are developing than when we see them in the research lab, where they may be scared or anxious.”

The researchers found that babies whose mothers had mild or asymptomatic COVID-19 during pregnancy were developing similarly to those whose mothers had never had COVID.

“The current study, which used a more rigorous method to evaluate babies born during the pandemic, provides further reassuring evidence that having a mild or asymptomatic case of COVID during pregnancy does not affect brain development in infants,” Dumitriu says. “Additional studies are needed to tell us about the impact of more severe COVID on a developing infant’s brain.”

Reference:

Firestein MR, Shuffrey LC, Hu Y, et al. Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy. JAMA Netw Open. 2023;6(4):e237396. doi:10.1001/jamanetworkopen.2023.7396