Nalbuphine may prevent postoperative delirium, agitation in kids undergoing ophthalmic procedures under GA
Perioperative pain management in children has long been a concern, and the occurrence of emergence delirium and agitation (EDA) after surgery is all too common. In a bid to address this issue, a recent study published in British Journal of Ophthalmology explored the use of nalbuphine as a potential solution for perioperative eye pain in children undergoing ophthalmic surgery under general anesthesia.
This retrospective cohort analysis involved 50 preschool-aged children who underwent ophthalmic surgery in a German university hospital between June 2020 and February 2021. These children were administered nalbuphine as a postoperative analgesic, and the impact on their pain management and incidence of EDA was closely monitored.
The group of children included 17 girls and 33 boys, with a median age of 20.5 months (ranging from 1 to 68 months) and a median body weight of 12.25 kilograms (ranging from 2.9 to 29 kilograms). As part of the standard procedure, all patients received ibuprofen at a dosage of 10 mg per kilogram during anesthesia induction. At the end of surgery, nalbuphine was administered at a dosage of 0.1 mg per kilogram.
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