Pediatric ARDS Study Shows Early Weaning Benefit With Lung-Diaphragm Protective Ventilation
USA: A randomized controlled trial conducted by Dr. Robinder G. Khemani and his team at the Keck School of Medicine, University of Southern California, suggests that using a targeted lung and diaphragm protective ventilation strategy in children may lead to quicker weaning from mechanical ventilation. The study, recently published in NEJM Evidence, explored whether a computer-guided ventilation approach could improve clinical outcomes in pediatric patients with acute respiratory distress syndrome (ARDS).
The trial, conducted at a single center between October 2017 and March 2024, enrolled 248 children who required mechanical ventilation for ARDS. Participants were randomly allocated into intervention and control groups at two key stages: the acute phase and the weaning phase of ventilation. The intervention group was managed using a computerized decision support system named REDvent, which was used with esophageal manometry to fine-tune ventilator settings with the goal of protecting both lung and diaphragm function. The control group received standard care at the clinician's discretion.
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