Probiotics use tied to Reduced Mortality in Preterm Infants: Study
According to a Canadian retrospective cohort study the use of probiotics in neonatal units was associated with decreased mortality in preterm and low-birth-weight infants. However Probiotic use did not significantly impact rates of necrotizing enterocolitis (NEC) or late-onset sepsis. Despite no change in NEC or sepsis rates, overall mortality was lower in infants who received probiotics. Results derived from information on more than 32,000 preterm infants, underscore the potential advantages and hazards of NICU use of probiotics. Pharmaceutical-grade probiotic access concerns, doubts about efficacy, and the possibility of probiotic sepsis have curative adoption on a large scale. The study was published in the journal Pediatrics.
The study reviewed data from 32,667 preterm babies, born under 34 weeks of gestational age; all were admitted in 33 NICUs across Canada between January 2016 and December 2022. Excluded from the analysis at admission were moribund infants, those who succumbed to death in the first two days, those admitted beyond two days after birth, those with severe congenital anomalies, and those for whom enteral feeds were never initiated.
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