S. aureus infection increases risk of atopic dermatitis in infants
Japan: Cheek skin colonized by Staphylococcus aureus is associated with the early development of developing atopic dermatitis in infants, according to a recent study in the Science Translational Medicine. However, despite the presence of bacteria on the skin, infants harboring S. aureus with acquired spontaneous mutations in Agr were more likely to remain healthy. The findings suggest that S. aureus and associated functional quorum sensing may play a role in AD onset in children (Inhibition of Staphylococcus aureus Agr–mediated quorum sensing is known to protect against AD).
Atopic dermatitis is commonly associated with colonization by Staphylococcus aureus in the affected skin. Yuumi Nakamura, Chiba University Graduate School of Medicine, Chiba, Japan, and colleagues performed whole-genome sequencing of S. aureus strains isolated from the cheek skin of 268 Japanese infants 1 and 6 months after birth, to understand the role of S. aureus in the AD development.
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