Scientists develop effective, safer and less costly polio vaccine
Bethesda, Md. – As the world nears poliovirus eradication, the vaccines themselves have become the greatest threat. In response to global demand for an effective, safer-to-handle and less costly polio vaccine.
Scientists at the Uniformed Services University (USU) have developed a new Polio vaccine one that could help secure a polio-free world. The promising results of research, "A Novel Gamma Radiation-Inactivated Sabin-Based Polio Vaccine," have been published in PLOS ONE.
In developing countries, the live Sabin oral polio vaccine (OPV) has generally been used because it has been more cost-effective than the injectable, inactivated polio vaccine (IPV). Now, both OPV and IPV are becoming tricky because children vaccinated with OPV can shed paralysis-causing mutant polioviruses, and because the manufacture of IPV uses deadly, "wild" viruses that are a biosecurity threat. Therefore, in a call to action, the World Health Organization (WHO) has urged the scientific research community to develop safer polio vaccines, ideally based on the use of inactivated "killed" Sabin viruses since they are much safer to handle than the "wild" viruses used in IPV production. The researchers believe this could lead to the production of a safer, less costly injectable polio vaccine.
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