Tree nut oral immunotherapy both safe and tolerable among Preschoolers

Dose escalations were performed every 2 to 4 weeks till a maintenance dose of 300 mg of TN protein was reached. The modified World Allergy Organization Subcutaneous Immunotherapy Reaction Grading System recorded from 1 as mildest and five as fatal was used for recording and classifying symptoms.

The study results could be summarised as follows:

• There were 92 patients starting tree nut oral immunotherapy TN-OIT ( 2018 – 2021).
• Seventy-nine patients underwent single-food TN-OIT, and 13 underwent multifood TN-OIT to 2 or 3 tree nuts.
• Maintenance was reached by Eighty-nine patients constituting 96.7%.
• Four patients constituting 4.3%, dropped out.
• Sixty-five constituting 70.7% of patients, experienced reactions during buildup with grade 1 reactions (35 patients), grade 2 reactions (30 patients), no grade 3 or 4 reactions, and 2 received epinephrine.

Further concluding, they wrote that “We find the results of the present study comparable to our previous study on peanut oral immunotherapy.”

Our study’s findings prove the safety and tolerability of TN-OIN in Preschool.

Further reading:

Real-World Safety Analysis of Preschool Tree Nut Oral Immunotherapy. https://doi.org/10.1016/j.jaip.2023.01.031