Antipsychotics fail to improve cognitive deficit in schizophrenia spectrum disorders: JAMA
A new study published in the Journal of American Medical Association showed that in individuals with schizophrenia spectrum disorders (SSD), not one antipsychotic was linked to superior cognitive results than a placebo. A significant portion of the symptoms of schizophrenia spectrum disorders include cognitive abnormalities, which also significantly increase the burden of the disease. Antipsychotic medications may have varying impacts on cognition because of their distinct receptor-binding characteristics, but they are not cognitive enhancers.
To ascertain if antipsychotic usage is connected with cognitive function in SSDs at all, no prior network meta-analysis compared antipsychotics to placebo. In order to rule out the relationship between therapy with different antipsychotics and cognition in patients with SSDs, Lena Feber and her team carried out this investigation. Through June 25, 2023, this research gathered information from 68 studies published between 1958 and 2022 that were part of the Cochrane Schizophrenia Trials Register. Blinded and unblinded randomized clinical studies that lasted at least 3 weeks and evaluated antipsychotics or antipsychotics vs placebo were included in the review.
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