ECT does not cause serious medical complications, confirms Lancet Study

In this retrospective cohort study done Kaster et al used linked population-based administrative health data for adult. The unit of analysis was individual admissions and propensity score matching was used to match each exposed admission to an unexposed admission to estimate the average treatment effect of electroconvulsive therapy among those treated.

The primary outcome was serious medical events, a composite of hospitalisation for medical (ie, non-psychiatric) reasons or non-suicide death within 30 days from electroconvulsive therapy exposure or matched date in the unexposed group. Secondary outcomes were medical hospitalisation and non-suicide death separately, suicide death, and specific serious medical events.

It was found that In this population-based study of more than 5000 admissions involving electroconvulsive therapy for inpatients with depression, the rate of serious medical events within 30 days was very low among those exposed to electroconvulsive therapy and a closely matched unexposed group (0•25 events per person-year vs 0•33 events per person-year), with those who received electroconvulsive therapy having a numerically lower risk of medical complications. Although the findings cannot exclude the possibility of a null or non-clinically significant risk, the results suggest that ECT does not result in a clinically significant increased risk of serious medical events.

This finding was consistent in analyses that additionally accounted for hospitalisation status, number of electroconvulsive therapy treatments, age, sex, and type of psychiatric diagnosis, and was robust to additional analysis considering suicide as a competing risk. In a secondary analysis among individuals with bipolar depression, electroconvulsive therapy was associated with a significantly lower risk for serious medical events. There also seemed to be a protective effect of electroconvulsive therapy on suicide risk within 30 days.

It can be thus concluded that the clinical implication of this study is that electroconvulsive therapy is likely to be safe with respect to medical risks; considering its established efficacy in depression, the benefits of electroconvulsive therapy might outweigh its risk in this severely ill population.

Source: Lancet Psychiatry: https://doi.org/10.1016/