Epigenetic clock "Grimage" gives proof for accelerated ageing in major depression.

Major depressive disorder (MDD) is associated with premature mortality and is an independent risk factor for a broad range of diseases, especially those associated with aging, such as cardiovascular disease, diabetes, and Alzheimer's disease. Protsenko et al have shown in their recent study that individuals with MDD exhibited significantly greater GrimAge( predictor of accelerated cellular ageing) relative to their chronological age compared to healthy controls, with a median of 2 years of excess cellular aging.
The pathophysiology underlying increased rates of somatic disease in MDD remains unknown. It has been proposed that MDD represents a state of accelerated cellular aging. Estimators of biological age based on predictable age-related patterns of DNA methylation (DNAm), so-called 'epigenetic clocks', have shown particular promise for their ability to capture accelerated aging in psychiatric disease. The recently developed DNAm metric known as 'GrimAge' is unique in that it was trained on time-to-death data and has outperformed its predecessors in predicting both morbidity and mortality.
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