Esketamine Nasal Spray Shown to Reduce Anhedonia in Treatment-Resistant Depression: Study
Written By : Dr. Shravani Dali
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2025-08-31 15:00 GMT | Update On 2025-09-01 05:39 GMT
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Researchers have found in a new study that repeated esketamine nasal spray use improved anhedonia in patients with unipolar and bipolar depression, independent of overall symptom changes. These findings highlight the potential of esketamine to target one of the most disabling symptoms of depression, which often persists despite standard treatment.
The study enrolled patients diagnosed with treatment-resistant depression who had not responded to at least two prior antidepressant therapies. Participants received esketamine nasal spray alongside standard-of-care treatment in a structured clinical setting. Anhedonia was assessed through validated self-report measures and clinician-administered scales over the course of treatment.
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