Extended-release naltrexone reduces alcohol consumption: Study
Extended-release naltrexone reduces drinking days and heavy drinking days per month suggests a study published in the Addiction.
A group of researchers from U.S.A conducted a study to:
o estimate the effect of extended-release naltrexone compared with placebo on alcohol consumption in patients with alcohol use disorder (AUD)
o conduct pre-planned subgroup analyses to test whether being abstinent when initiating treatment (lead-in abstinence) or the duration of treatment improves treatment efficacy.
This study was a systematic review and random-effects meta-analysis of blinded randomized placebo-controlled trials reporting the effect extended-release naltrexone on alcohol consumption, and included out-patient patients.
The researchers conducted a total of seven trials evaluating a total of 1500 adults with AUD receiving monthly injections of either placebo or extended-release naltrexone at doses of 150–400 mg for 2–6 months and some form of behavioural therapy. Pooled weighted mean difference (WMD) in drinking days per month and heavy drinking days per month.
The results of the study are as follows:
· The WMD was −2.0 [95% confidence interval in favour of extended-release naltrexone for drinking days per month and −1.2 for heavy drinking days per month, indicating that treatment resulted in two fewer drinking days per month and 1.2 fewer heavy drinking days per month compared with placebo.
· Trials not requiring lead-in abstinence and those lasting longer than 3 months reported larger reductions in heavy drinking days per month; WMD –2.0 and −1.9, respectively.
· In all cases, the I2 statistics did not suggest substantial heterogeneity.
Thus, the researchers concluded that extended-release naltrexone reduces drinking days and heavy drinking days per month compared with placebo. Reductions are larger with a longer duration of treatment.
Reference:
A study titled, "Effect of extended-release naltrexone on alcohol consumption: a systematic review and meta-analysis" by Murphy C et. al published in Addiction.
https://doi.org/10.1111/add.15572
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.