Immunodeficiency strongly linked with suicide, psychiatric disorders: JAMA
Sweden: Primary humoral immunodeficiency (PID) is associated strongly with suicidal behavior and lifetime psychiatric disorders, suggests a recent study in the journal JAMA Psychiatry. The association was found to be more stronger in women and could not be explained fully by co-occurrence of autoimmune diseases. Also, the patients with both autoimmune disease and PID were at the highest risk of suicide and psychiatric disorders.
PIDs are rare deficiencies of the immune system that are associated with adverse health problems such as autoimmune disease and recurrent infections. The etiological importance of disrupted immune function in psychiatric disorders has been demonstrated in many studies. However, not much is known about neuropsychiatric consequences resulting from the underproduction of homeostatic antibodies. Considering this Josef Isung, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden, and colleagues aimed to establish whether PIDs that affect antibody function and level are associated with lifetime psychiatric disorders and suicidal behavior. And also, whether this association is explained by the co-occurrence of autoimmune diseases.
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