JAMA study links toxoplasma seropositivity with impaired cognition

13 studies comprising 13 289 healthy participants with and without T gondii seropositivity were included in the meta-analysis. Participants without T gondii seropositivity had favorable functioning in 4 cognitive domains:

1. Processing speed

2. Working memory

3. Short-term verbal memory

4. Executive functioning

A meta-regression analysis found a significant association between older age and executive functioning. Although the extent of the associations was modest, the ubiquitous prevalence of the quiescent infection worldwide (approximately 30%) suggests that the consequences for cognitive function of the population as a whole may be substantial, although it is difficult to quantify the global impact.

Furthermore, a recent meta-analysis found a marginally significant association between T gondii seroprevalence and Alzheimer disease. (1)

Based on the present findings and those of previous meta-analyses examining the association of T gondii seropositivity with motor vehicle crashes, suicide attempts, and the prevalence of psychiatric disorders, public health programs to prevent T gondii infection are warranted.

These programs might, at a minimum, consist of hygienic measures, especially after human contact with contaminated sources. Hygienic measures are often already undertaken to prevent other infectious diseases. However, these measures are not sufficient to prevent quiescent T gondii infection. It may be wise to consider further research into the development of a vaccine against infection with T gondii in either humans or felids.

Source: JAMA Psychiatry: doi:10.1001/jamapsychiatry.2021.1590

Reference: 1. Bayani M, Riahi SM, Bazrafshan N, Gamble HR, Rostami A. Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: a systematic review and meta-analysis on observational studies. Acta Trop. 2019;196:165-171.