Long-Acting Injectable Antipsychotics Effective for Bipolar, schizoaffective disorders among adolescents: Study
Long-Acting Injectable Antipsychotics Effective Bipolar and schizoaffective disorders among adolescents, finds study published in the Journal of Child and Adolescent Psychopharmacology.
Bipolar disorder often begins in adolescence or early adulthood and is characterized by recurrent manic episodes that can lead to neurodegenerative brain changes and functional decline.While several oral second-generation antipsychotics are Food and Drug Administration (FDA)--approved for mania, adherence to maintenance treatment is frequently poor due to factors such as anosognosia, cognitive dysfunction, impulsivity, side effects aversion, and substance use. Long-acting injectable (LAI) antipsychotics, approved for adults with bipolar mania or schizoaffective disorder (bipolar type), offer a potential solution for adolescents with similar conditions.
This study reports on the efficacy of LAI antipsychotics in managing bipolar mania in adolescents, tracking outcomes over up to a year with baseline and follow-up Young Mania Rating Scale (YMRS) assessments. Methods: The study included 116 adolescents with a mean age of 16.17 years (66% male, 48% white, 23% black). Of these, 73% were diagnosed with bipolar mania and 22% with schizoaffective disorder, bipolar type. The mean illness duration was 1.9 years, with a baseline YMRS score of 33.8 and a body mass index (BMI) of 23.4 kg/m². LAI antipsychotics administered included aripiprazole, paliperidone, and risperidone, given at intervals of 1, 2, or 3 months.
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