Low dose clozapine effective in Indians with drug induced tardive dyskinesia and dystonia, finds study
A new study published in the Asian Journal of Psychiatry showed that people of Indian heritage require lower effective dosages of clozapine for drug induced tardive dyskinesia and tardive dystonia when compared to Western populations. Long-term usage of dopamine antagonists can cause delayed-onset movement problems known as tardive syndromes (TS). Clozapine has been recommended for the treatment of TS in earlier research, showing symptom relief in as little as 1 to 3 months. Thus, by examining the clinical records of patients at a tertiary care hospital who first reported with tardive dyskinesia, tardive dystonia, or both, this retrospective study by Sandeep Grover and his team assessed the long-term efficacy of clozapine in treating TS.
Reduction of symptoms on the Unified Dystonia Rating Scale (UDRS) and Abnormal Involuntary Movement Scale (AIMS) was the main end measure. A total of 66 participants from a larger cohort of 1050 patients who mostly suffered from schizophrenia and a lesser percentage with affective disorders were included in the current study. All of the patients were followed for TS after using antipsychotics for an extended period of time.
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