Major psychiatric disorders share common gut-microbiota alterations, JAMA study
Recent evidence has emerged regarding significant links between gut bacteria and various psychiatric disorders. But, do psychiatric disorders present with distinct or shared gut microbial alterations?
Patients with depression, bipolar disorder, schizophrenia, and anxiety may share a common perturbation of gut microbiota- as shown by a recent systematic review and meta-analysis published recently in JAMA Psychiatry. The study conducted by Nikolova et al has suggests a common transdiagnostic pattern of gut organisms with depletion of certain anti-inflammatory butyrate-producing bacteria and an enrichment of pro-inflammatory bacteria is common to afore-mentioned psychiatric disorders and may serve as a potential biomarker.
Preclinical studies have consistently demonstrated that fecal microbiota transplants from patients with a wide range of psychiatric conditions result in the development of the behavioral and physiological profile of the condition in germ-free mice. This suggests that psychiatric disorders may be associated with a distinct pattern of microbial perturbations, which may serve as a biomarker.
The current study included a total of 59 case-control studies, evaluating diversity or abundance of gut microbes in adult populations with major depressive disorder, bipolar disorder, psychosis and schizophrenia, anorexia nervosa, anxiety, obsessive compulsive disorder, posttraumatic stress disorder, or attention-deficit/hyperactivity disorder were included.
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