Minocycline as adjuvant not superior to placebo in reducing symptoms in patients with resistant depression
Minocycline is not superior to placebo in reducing depressive symptoms in patients with Treatment-Resistant Depression according to a recent study published in the JAMA Network Open.
A study was conducted to determine whether 6 weeks of minocycline as an add-on to antidepressant treatment, as usual, can significantly reduce depressive symptoms in patients with Treatment-Resistant Depression.
The study was conducted in Germany and designed as a multicenter double-blind randomized clinical trial (RCT) of 200 mg/d minocycline treatment over a course of 6 weeks with a 6-month follow-up. Participants were recruited from January 2016 to August 2020 at 9 university hospitals that served as study sites. Key inclusion criteria were a diagnosis of major depressive disorder (according to Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition] criteria), the severity of depressive symptoms on the Hamilton Depression Rating Scale (HAMD-17) greater than or equal to 16 points, aged 18 to 75 years, body mass index 18 to 40, Clinical Global Impression Scale (CGI-S) greater than or equal to 4, failure to adequately respond to an initial antidepressant standard medication as per Massachusetts General Hospital Antidepressant Treatment History Questionnaire, and stable medication for at least 2 weeks. A total of 258 patients were screened, of whom 173 were randomized and 168 were included in the intention-to-treat population. Statistical analysis was performed from April to November 2020.
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