Music Impulse Stimulation effective as add on treatment for depression

The results of the study were

• A total of 38 participants out of which 18 patients were randomized to the add-on treatment and 20 patients to the control group.

• Both groups were assesed in Hamilton Depression Rating Scale (HDRS)-17 and in HDRS-6, although the HALF-MIS group had a greater decline of symptoms.

• A significant difference in intergroup analysis (p = .011, CI 95% for the HALF-MIS group 3.0588–8.5327 and CI 95% for the control group 0.2384–3.0) was found.

• The (HDRS)-6 difference was also significant (p = .020, CI 95% for the HALF-MIS group 1.5911–5.0487 and for the control group −0.297 to 1.7058). No side effects were observed.

Dr Sigurdardottir and team concluded that "High Amplitude Low Frequency–Music Impulse Stimulation treatment seems to give beneficial effect as an add-on treatment for depression. HALF-MIS appears to be a safe and effective add-on treatment for depression." However, this study was limited in that there was a small sample size as well as heterogeneity in the antidepressants used between participants. Nonetheless, HALF-MIS represents a non-invasive adjunct to traditional depression interventions which may decrease symptoms and improve quality of life.

For further information: https://doi.org/10.1002/brb3.1399