New data supports an association of depression with triglyceride glucose index among adults
China: A recent study published in Medicine has revealed an association between depression and triglyceride glucose (TyG) index. Thus, insulin resistance (IR) appears to be a risk factor for depression.
Major depressive disorder (MDD) is a common mental illness that has impacted human health and garnered widespread global attention. According to the WHO, depression will become the world’s leading health problem by 2030. However, existing antidepressants were developed based on the monoamine neurotransmitter hypothesis, and are not always clinically effective, showing a clinical response rate of <70%. Therefore, it is urgent to discover the pathogenesis of depression and possible therapeutic targets.
The TyG index can be used for IR assessment. The index is based on fasting triglyceride (TG) levels and glucose rather than glucose and insulin. TyG is suggested to be more convenient for clinical use and is an inexpensive and reliable alternative test for IR estimation. Previous studies have indicated interactions between insulin resistance and depression.
Against the above background, Peiyuan Lv, Department of Neurology, Hebei Medical University, Shijiazhuang, China, and colleagues investigated the association between the TyG index and depression to evaluate the presence of insulin resistance in depression. They also determined whether there is a difference between depressed patients and healthy controls.
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