Novel Combination Therapy Xanomeline-Trospium Promising for Treatment of Schizophrenia: JAMA
Researchers have found that the investigational combination of xanomeline-trospium (KarXT) is effective and well-tolerated in individuals with schizophrenia who are experiencing acute psychosis. The randomized controlled phase III EMERGENT-3 trial demonstrated that the combination therapy significantly reduced Positive and Negative Syndrome Scale (PANSS) total scores over five weeks compared to placebo, indicating its potential as an alternative treatment option. This study was published in the journal JAMA Psychiatry by Kaul and colleagues.
Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. Traditional antipsychotic medications often target dopamine receptors, but the combination therapy of xanomeline-trospium represents a new approach that does not involve D2 dopamine receptor blocking activity.
The EMERGENT-3 trial was a randomized, double-blind, multicenter, placebo-controlled trial involving 256 participants aged 18 to 65 with a diagnosis of schizophrenia. Participants were assigned to either the xanomeline-trospium group (n=125) or the placebo group (n=131). The xanomeline-trospium group received varying doses of the combination therapy over the five-week treatment period, while the placebo group received a placebo.
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