Omega-3 PUFA supplementation fails to improve symptoms of Adolescent Depression: Study
Researchers have found that while omega-3 polyunsaturated fatty acid (PUFA) supplementation might just modestly be associated with smaller effects on self-reported depression symptoms in adolescents, the evidence is very uncertain. A recent study was conducted by Susan C. and colleagues published in Cochrane Database Systematic Reviews.
Adolescent depression has become an increasingly alarming public health issue, with a rise of more than 25% during the COVID-19 pandemic. The problem is compounded by the unavailability of accessible mental health services. Omega-3 PUFA, with its established anti-inflammatory effects and modulatory action on neurotransmission, has been advocated for adults experiencing depression; however, its efficacy and safety in younger populations to treat depression remain less explored and thus warranted this comprehensive synthesis of existing evidence.
This review enrolled five RCTs in patients aged 19 or younger diagnosed with depression and had 228 participants. Comparators utilized were placebo, wait-list controls, no treatment, or standard care. Trials ranged from 10–16 weeks, and the median was 12 weeks. Followed were self-reported depression symptoms, clinical remission of depression, attrition rates, adverse effects, and compliance. GRADE methodology was utilized to assess the degree of certainty in the evidence.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.