Schizophrenia may increase risk of cardioembolic stroke, finds JAHA study
A recent study looked into the intricate relationship between schizophrenia and stroke by uncovering the potential links between the mental disorder and specific stroke subtypes. While previous studies hinted at a connection between schizophrenia and stroke, this investigation was marked to be the first to explore stroke subtypes in detail. The key findings were published in the recent edition of the Journal of the American Heart Association.
This study employed two-sample Mendelian randomization analyses and focused on unraveling potential causal associations between schizophrenia and various stroke outcomes, including ischemic stroke, large-artery stroke, small-vessel stroke, cardioembolic stroke and intracerebral hemorrhage.
The findings revealed compelling associations between schizophrenia and two specific stroke subtypes the cardioembolic stroke and intracerebral hemorrhage. After utilizing the inverse variance weighting method, Shinya Nakada and team identified a significant association between schizophrenia and cardioembolic stroke (odds ratio [OR] 1.070 [95% CI, 1.023–1.119]) that suggests a potential causal relationship. The association with intracerebral hemorrhage (OR 1.089 [95% CI, 1.005–1.180]) was observed amidst less robust evidence.
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