Solriamfetol safe and effective for treating excessive daytime sleepiness, finds study
Nepal: Solriamfetol is safe and effective for the treatment of excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA) or narcolepsy, a recent study in the journal Sleep Medicine.
Solriamfetol is a selective norepinephrine-dopamine reuptake inhibitor approved for EDS. Excessive daytime sleepiness is the inability to maintain alertness and wakefulness during the daytime. In EDS sleep occurs unintentionally or at inappropriate times. Excessive daytime sleepiness is a symptom of narcolepsy and obstructive sleep apnea.
Roshan Subedi, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal, and colleagues performed this review to assess the efficacy and safety of solriamfetol in patients with EDS in narcolepsy or OSA.
The researchers conducted a systematic search of the electronic database for relevant studies. Inclusion criteria were RCTs with outcome measures on the efficacy or safety of solriamfetol in EDS. They identified 336 records from the database search. Eight articles reported from six clinical trials were analyzed. Outcome measures were pooled from five trials.
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