New Guidelines Recommend Shorter, All-Oral Regimens for Drug-Susceptible and Drug-Resistant Tuberculosis
USA: An international panel of experts has released guidelines advocating for shorter, all-oral drug regimens for both drug-susceptible (DS) and drug-resistant (DR) tuberculosis (TB) in adults and children.
The clinical practice guideline developed by the American Thoracic Society (ATS), Centers for Disease Control and Prevention (CDC), European Respiratory Society (ERS), and Infectious Diseases Society of America (IDSA) has updated recommendations for treating both drug-susceptible and drug-resistant tuberculosis. The guideline emphasizes a shift toward all-oral, shorter treatment regimens, which significantly improve patient adherence, convenience, and overall treatment outcomes.
The guidelines, published online in the American Journal of Respiratory and Critical Care Medicine, are derived from recent clinical trial data and adapted from the World Health Organization's (WHO) 2022 consolidated guidelines on tuberculosis. The joint panel comprised 25 experts in pulmonary medicine, infectious diseases, pediatrics, epidemiology, and public health, alongside a patient advocate.
Key Recommendations Include:
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